Archive for April 2026
When AI Meets Real Patients: Inside Sanofi’s AI-Powered Clinical Development Pipeline
In Part 1 of our conversation with Matt Truppo, the story was about AI doing hard science: finding drug targets, designing molecules, engineering proteins. The risks were manageable. “The risk of letting the AI take on some decisions autonomously is very, very low,” Truppo told us, describing the preclinical side. Part 2 is a different…
Read More50 Years of Clinical AI: What We Built, What We Lost, What Still Hasn’t Changed
The Question That Never Changed Fifty years into the story of medical AI, one question has never changed. In the early 1980s, Ted Shortliffe and his team published a study in Computers and Biomedical Research documenting what physicians would require before trusting a computer-based clinical decision support aid. The answer: “We don’t want to use…
Read MoreWhen AI Moves Past the Mundane: Inside Sanofi’s Drug Discovery Pipeline
For 30 episodes of Practical AI in Healthcare, we’ve documented a recurring pattern. Guest after guest, the real AI wins show up in operations: scheduling, documentation, billing, claims processing. We even coined a shorthand for it: “Mundane Wins Matter.” Then we sat down with Matt Truppo. The wins are in the hard science Truppo is…
Read MoreThe AI Works. Now What?
The convergence nobody planned We didn’t ask our guests to coordinate. Giovanni Donatelli builds medical translation infrastructure. Charlie Harp measures data quality. Adam Blum matches cancer patients to clinical trials. Shashi Shankar is building patient-authorized real-world data sets. Amy Price advocates for patients as co-designers of their own care. Five completely different domains. Five working…
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